An Update on the Prospect of a Cure for Alzheimer’s

A recent article provides an update on the prospect of a cure for Alzheimer’s.1 Here are some quotes from the article, attributed to neuropsychologist Peter J. Snyder, “There’s not going to be a single magic bullet… This isn’t a disease, but a syndrome with multiple etiologies.” Long time readers of the healthymemory blog might remember that Alzheimer himself was doubtful that this was a disease. His employment situation motivated him to make that argument (see the healthymemory blog post, “Sigmoid Freud and Alzheimer’s Disease”).

Previous healthymemory blog posts have made the point that autopsies of individuals who had never shown signs of Alzheimer’s were found to have substantial buildups of amyloid plaque and neurofibrillary tangles. That led me to conclude that the amyloid plaque and neurofibrillary tangles might be a necessary, but not a sufficient cause of Alzheimer’s. However, recent imaging studies have shown that about 30 percent of healthy adults who never develop Alzheimer’s have fairly substantial plaque buildups. A less common occurrence is people who have classic symptoms of Alzheimer’s but no amyloid in the brain. Consequently I have come to the conclusion that amyloid plaque and neurofibrillary tangles are neither a necessary nor a sufficient condition for Alzheimer’s.

It is important to note that large portion of the research on Alzheimer’s was targeted at this amyloid plaque and neurofibrillary tangles. This is an indication of how far off the mark this research has been. The conclusion reached by Snyder is that a cure for Alzheimer’s is not within reach. However, he argues that “If we can slow the progression by just five years, we can cut the cost of Alzheimer’s to society by 2050 by almost 50 percent. It’s an attainable goal.’

I would like to see the logic and the computations regarding this last statement. Won’t slowing the progression increase the duration of the disease and hence the costs? For myself, I have no interest in a treatment that will prolong the disease, prolong my agony.

There is the new Brain Research through Advancing Innovative Technologies (BRAIN). I am wildly enthusiastic about this project, and I am confident that much will be learned. However, I fear that it has been oversold with respect to cures for brain diseases and brain injuries. I hope I am wrong, but I am afraid that I am not.

And for you Baby Boomers , a cure is unlikely. Start building your cognitive reserve by following recommendation in the healthymemory blog and in similar publications. If you have not already, start building a healthy memory and a cognitive reserve (if you don’t know what a cognitive reserve is enter “cognitive reserve” into the search block of the healthymemory blog).

1Voelker, R. (2013) The pre-Alzheimer’s Brain. Monitor on Psychology, March, 46-49.

© Douglas Griffith and healthymemory.wordpress.com, 2013. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

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