REST, Epigenesis, Neuroplasticity, Cognitive Reserve, & Alzheimer’s

The March 19 Washington Post published an article written by Angela Zimm, “Fetal brain protein reactivates in old age, may fight dementia.” The research was conducted by scientists at Harvard University and published in the journal Nature. It reported that a protein called REST is depleted in the brains of people with Alzheimer’s. It was found at a level three times as high in people who did not experience dementia even when their brains had indications of the disease. According to Yanker, a professor of genetics at Harvard Medical School in Boston, “There’s a long-standing puzzle in neurology why a large percentage of the aging population when they die have enough abnormalities in the brain to classify as Alzheimer’s, though they don’t develop the dementia.”
This is a rarely publicized fact about Alzheimer’s, that there are many people who do not exhibit the symptoms of dementia even though their brains at autopsy are found to have the so-called tell tale neurofibrillary tangles and amyloid plaques. These are the only signs that allow a conclusive diagnosis of Alzheimer’s . So it appears that these tangles and plaques might be a necessary, but not a sufficient condition for Alzheimer’s disease. Most research on Alzheimer’s has been on attacking the tangles and plaques.
The only explanation that has been offered is that the people with the tangles and plaques, but not Alzheimer’s have built up a cognitive reserve to fend off this disease. Indeed, this is one of the exhortations of the healthymemory blog, to build up a cognitive reserve/. However, what has been lacking to this point is an explanation as to how this cognitive reserve is built up. The process of epigenesis is one possible mechanism for the release and maintenance of the REST protein. Possible mechanisms for building a cognitive reserve can be found in the healthymemory blog, “What is Neuroplasticity and How Does it Work”, and include, in addition to epigenesis, synaptogenesis, myleinogenesis, and neurogenesis. The healthymemory blog post, “Supporting Neuroplasticity” lists some specific practices that could aid in building a cognitive reserve.

© Douglas Griffith and, 2014. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and with appropriate and specific direction to the original content.


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One Response to “REST, Epigenesis, Neuroplasticity, Cognitive Reserve, & Alzheimer’s”

  1. The Alzheimer’s Project: Momentum in Science is Available at All Books Stores! | Says:

    […] REST, Epigenesis, Neuroplasticity, Cognitive Reserve, & Alzheimer’s […]

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