Cognition Enhancing Drugs

Cognition Enhancing Drugs is the title of a chapter in Nurturing the oder Brain and Mind By Greenwood and Parasuaman.  They note that “there is little doubt that estrogen protects both the brain and cognitive functioning not only in younger female animals and in women undergoing surgical menopause, but also in middle-aged women around the time of natural menopause.  Unfortunately subsequent research revealed  the health risks of initiating estrogen and progesterone use in women many years after menopause.  However, the situation is confusing as  additional research has been conflicting and the situation remains unresolved.    Greenwood and Parasuraman conclude, “We should await results from newer better-designed studies before drawing conclusions about the benefits and costs of estrogen in women.”

Greenwood and Parasuraman note that the effects of other cognitive-enhancing drugs on older people have been little studied.  Perhaps this is because research has been targeted at  developing drugs that either cure of prevent Alzheimer’s.   Drugs that have been developed only slow the progression of the disease.  To my way of thinking this is only prolonging the agony.  Moreover, there is reason to believe that a drug that cures or prevents Alzheimer’s might never be developed (See the healthy memory blog post, “The Myth of Alzheimer’s”).

Greenwood and Parasuraman find it strange that the benefits of  cholinergic agonists for benefits in young people, that cholinesterase inhibitors have been so little studied in older people.  Again, in my view, this is due to the preoccupation with finding a cure or a preventive vaccine.  Perhaps as a result of their review some attention will be turned to this approach.
Caffeine is beneficial, but with this exception there is no current compelling evidence that pharmacological agents are useful for ameliorating cognitive aging.

© Douglas Griffith and healthymemory.wordpress.com, 2014. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

 

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