Mindfulness and Alzheimer’s

This post is taken in part from “Siddhartha’s Brain”  by James Kingsland.  There is evidence that one of the benefits of mindfulness is to slow age-related cognitive decline and perhaps even protect against Alzheimer’s Disease.  Deposits of beta-amyloid, the protein plaques that are characteristic of the disease are concentrated in the default mode network.  This includes its principal hub, the posterior cingulate cortex, and the medial temporal lobe, where structures such as the hippocampus create and store long-term memories.  When people are not focused but performing an externally directed task, the parts of the brain that become active closely match the areas most vulnerable to the damage associated with Alzheimer’s.  Animal research, using mice genetically engineer to develop amyloid plaques, built up exclusively in areas of high nerve activity.

So, in theory, not just mindfulness but any pastime that hold’s the mind’s eye steady and stops attention from wondering, whether it’s a sport  solving puzzles, math, reading, studying, or the mindfulness awareness of everyday activities cultivated by meditation, will give the brain’s default mode network a break and make it less likely that amyloid plaque will accumulate.

Although this is good news, readers of the healthy memory blog should be aware that people have died with the defining physical symptoms, the neurofibril tangles and amyloid plaque, without knowing that they have had the disease.  That is they never evidenced any of the behavioral or cognitive symptoms of he disease.  The explanation for these people is that through the way they used their brains during their lifetimes they built up a cognitive reserve.  The healthy memory blog promotes activities that should build up a cognitive reserve.

Kingsland notes that there is preliminary evidence that meditation can slow or even reverse age-related brain degeneration, helping to maintain the thickness of the cortex and prevent loss of gray matter (nerve cell bodies) and white mater (merve fibers or “axons”.  The reference for this is
Luders, E.  (2014) “Exploring Age-Related Brain Degeneration in Meditation Practioners,”  Annals of the New York Academy of Sciences 1307:82-88.

© Douglas Griffith and healthymemory.wordpress.com, 2016. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.


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