Posts Tagged ‘neurofibrillary tangles’

The Use of Unproven Supplements

November 30, 2019

This post is based on an article titled “Study shows half of middle-aged Americans fear they’ll get dementia, use unproven supplements, in the Health & Science section of the 26 November 2019 issue of the Washington Post. The article begins, “About half of middle-aged Americans believe that they’re “very likely” to develop dementia a survey suggests, and many try to beat the odds with supplements such as ginkgo biloba and vitamins that aren’t proven to help.”

Data from the University of Michigan’s 2018 National Poll on Healthy Aging consists of a nationally representative survey of adults 50 to 80. 44.3% of the respondents said they were at lease somewhat likely to develop dementia, and 4.2% said they were very likely to develop dementia. Just 5.2% of the respondents said they had discussed dementia prevention with their doctors.

Regardless, 31.6% said they took fish oil or omega-3 fatty acids hoping that it would help lower the risk, and 39.2% took other vitamins or supplements. More than half of participants also believe doing crossword puzzles could help stave off dementia.

Study leader Donovan Maust of the University of Michigan wrote in the journal JAMA Neurology, “Given repeated failures of disease-preventing or disease modifying treatments for dementia, interest to treatment and prevention have shifted earlier in the disease process.”

These unproven supplements don’t work. Those who are solving crossword puzzles are on the right track, but more, prolonged cognitive effort is needed to stave off the disease. Similarly, certain computer games might be helpful, but playing them alone is insufficient.

The Alzheimer’s Association and drug developers are working on drugs to stop or eliminate the neurofibrally tangles and amyloid plaque, which are the defining characteristics of the disease. A former researcher into these drugs has argued that such drugs will never be discovered or developed. His arguments can be found in the healthy memory blog post titled The Myth of Alzheimer’s as well as in a book by the same title authored by Peter J. Whitehouse, M.D., Ph.D, and and Daniel George, M.Sc.

Moreover, many people have died and their autopsies have shown that their brains with these defining characteristics of the disease, but who never realized they had the disease, because they never had any of the cognitive or behavioral symptoms.

The reason offered for this result is that these individuals had built up a cognitive reserve. Cognitive activity had built up their brains so that, when they had these physical manifestations, their brains were able to work around them.

This is why the healthy memory blog strongly recommends growth mindsets where active reading and learning is maintained throughout one’s lifetime. This must also be supplemented by a healthy lifestyle. The practice of meditation and mindfulness can facilitate this healthy lifestyle.

© Douglas Griffith and healthymemory.wordpress.com, 2019. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

Alzheimer’s Disease (AD)

September 24, 2019

This post is based on an important book by Scott D. Slotnick titled “Cognitive Neuroscience of Memory.” Remember to consult the website http://www.brainfacts.org/
to see the anatomical information referred to in this post.

As AD progresses from earlier to later stages, atrophy starts in the medial temporal lobe, extends to the parietal lobe, and finally includes the frontal lobe. The long-term memory impairment in early AD patients can be attributed to the disrupted processing in the hippocampus and parietal cortex, to regions that have been associated with this cognitive process. As the disease progresses, other cognitive processes are disrupted such as attention and language, which both depend on the dorsolateral prefrontal cortex.

In early AD patients, as atrophy begins in the parietal cortex and the frontal cortex, there have also been reports of increases in fMRI activity within cortical regions. It is unknown whether these increases in cortical fMRI activity reflect a compensatory mechanism, which is often assumed to be the case, or reflect non-compensatory hyperactivity due to neural disruption.

In addition to brain atrophy, AD patients have abnormal high levels of proteins in different brain regions. In the medial temporal lobe, the accumulation of tau protein leads to neurofibrillary tangles. In cortical regions, such as the parietal cortex in early AD, the accumulation of amyloid-B protein leads to amyloid plaques. The neurofibrillary tangles in the medial temporal lobe and amyloid plaques in cortical regions can be assumed to disrupt neural processing in these regions.

Dr. Slotnick writes, “There is an influential hypothesis that there is a causal relationship between default network activity that leads to deposition of amyloid that results in atrophy and disrupted metabolic activity, which impairs long-term memory in AD patients. The regions in the default network are active when participants are not engaged in a task and include the dorsolateral prefrontal cortex, the medial prefrontal cortex, the inferior prefrontal cortex and the medial parietal cortex. In AD patients, amyloid deposition occurs in the same regions, which suggest the default network activity may lead to amyloid deposition. Dr. Slotnick suggests that perhaps higher level of amyloid deposition, which occurs in late AD patients, is necessary to produce atrophy in the frontal cortex.

Healthy memory readers should recognize the similarity between the default network and Kahneman’s System 1 processing. System 1 processing is the default network that needs to be disrupted to engage in System 2 processing, better known as thinking.

Dr. Slotnick continues, “If high amyloid deposition is a causal factor in developing AD, older adults with low levels of amyloid should be at decreased risk for developing this disease. There is some evidence that cognitive engagement and exercise throughout life may reduce the amyloid level in the brains of healthy older adults as a function of cognitive engagement (System 2 processing), and this was compared to the cortical amyloid levels . Participants rated the frequency which they engaged in cognitively demanding tasks such as reading, writing, going to the library, or playing games at five different ages (6, 12, 18, 40, and their current age). Healthy older adults with greater cognitive engagement throughout their lifetime, as measured by the average cognitive activity at the five ages, had lower levels of amyloid in default network regions. Moreover, the healthy older adults in the lowest one-third of lifetime engagement had amyloid levels that were equivalent to AD patients, and the healthy older adults in the highest one-third of lifetime cognitive engagement had amyloid levels that were equivalent to young adults.

It should also be noted that many have died who upon autopsy had levels of amyloid plaque and neurofibrillary tangles definitive of AD, but who never exhibited any of the behavioral or cognitive symptoms characteristics of the disease. The explanation typically offered for these individuals is that they had built a cognitive reserve as a result of the mental activities they had engaged in during their lifetimes.

There is a wide variety of products sold to prevent AD, such as computer games and pills that increase short-term memory. But it should be clear from the posts on cognitive science that the entire brain is involved. That is why the healthy memory blog strongly recommends growth mindsets with continual learning throughout the lifespan. These make heavy use of System 2 processing. Of course, a healthy lifestyle that includes physical exercise must also be part of the mix.

The Brain Can Do Very Much with Very Little

August 5, 2019

This is the sixth post on a new series of posts on Healthy Memory. The defining characteristics for Alzheimer’s are the accumulation of amyloid plaque and neurofibrillary tangles. So if you have these characteristics, you have this disease. However, autopsies have revealed people with these defining characteristics who never exhibited any cognitive or behavioral symptoms. The explanation offered is that these people developed a cognitive reserve as a result of their cognitive activities.

A man with only 10% of his cortex earned a bachelor’s degree in mathematics. People with the defining characteristics of Alzheimer’s, but no behavioral or cognitive symptoms likely develop new routes for storing and retrieving information. We generate new functioning neurons (we continue to generate neurons until we die.)

Healthy memory strongly supports the contention that System 2 processes are central to building this cognitive reserve.

So the healthy memory blog strongly recommends:

staying cognitively active to the very end by engaging in heavy system 2 processing

having a growth mindset that pursues continuing to learn until the very end

living a healthy life style

There is one more activity that is important that will be discussed in the next post

Alzheimer’s Researchers Shift Focus After Failures

July 7, 2019

The title of this post is identical to the title of a front page article by Christopher Rowland in the 4 July 2019 issue of the Washington Post. These researchers are shifting their focus to new drug treatments that deal with other factors than the defining features for an Alzheimer’s diagnose, which are amyloid plaque and neurofibrillary tangles. The conclusion that this research is fruitless was made by a former researcher in this area. The Myth of Alzheimer’s is a book by Peter J. Whitehouse, M.D. and Ph.D and Daniel George, M.Sc. Whitehouse is the former researcher who came to the conclusion that this research would never yield results. There was a healthy memory post on this book in 2011. HM believes Dr. Whitehouse is working on non drug treatments for Alzheimer’s. The Alzheimer’s association provides little, if any, support in this area. The Alzheimer’s association provides financial support for drug research. HM wonders in the unlikely event that a useful drug was produced, whether the Alzheimer’s Association had some agreement to limit costs or would this company be allowed to prey on the public. Before giving any money to the Alzheimer’s association, potential donors should demand an answer to this question.

There have been many posts on this topic including one titled “The Myth of Alzheimer’s.” Perhaps the most significant finding is one that is rarely, if ever, mentioned. And that is that people die with the defining characteristics for an Alzheimer’s diagnosis, the amyloid plaque and neurofibrillary tangles, but who never knew that they had the disease because they never had any behavioral or cognitive symptoms of the disease. The explanation offered is that these people had developed a cognitive reserve as a result of being cognitively active during their lifetimes.

The reappearing theme in this blog is that people should live cognitively fulfilling lives with growth mindsets in which they are continuing to learn. This involves System 2 processing, more commonly referred to as thinking. Our normal processing mode is System 1, which is quite fast and efficient. Here we are in cruise control where the conscious content just keeps flowing. As one proceeds through life this becomes easier and easier. Much has been learned, there is little interest in learning anything new, so the mind effectively is on cruise control. Cognitive neuroscience has termed this the default mode network, which is quite similar, if not identical, to Kahneman’s System 2 processing which is from cognitive psychology.

HM knows people who have been cognitively active throughout their lives, yet still succumbed to Alzheimer’s or dementia. But there are other causes. One of HM’s friends trained himself to get by on 4 hours of sleep per night. Research shows us that 7 to 8 hours of sleep are required. Other ambitious people burn the candle and both ends, which also leads to sleep deprivation.

HM wishes the researchers well in their research. But everyone should know that by engaging in a cognitively challenging life with growth mindsets they should greatly decrease, if not eliminate, the prospect of dementia or Alzheimer’s. Of course, a healthy lifestyle is also assumed.

Please use the search block of the blog (healthymemory.wordpress.com) to learn more about any of the terms in this post.

© Douglas Griffith and healthymemory.wordpress.com, 2019. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

Missing Healthymemory Themes

April 26, 2019

HM was disappointed that Dr. Twenge did not at least touch upon healthy memory themes in “iGEN: Why Today’s Super-Connected Kids are Growing up Less Rebellious, More Tolerant, Less Happy—and Completely Unprepared for Adulthood.” One of these themes was alluded to in the posts about spirituality and religion. There seems to have been a loss in empathy among iGen-ers. Given the exorbitant college costs along with other economic demands, the iGen-ers are living in a dog eat dog world. Spiritual activities including meditation can increase sensitivity to and caring for our fellow human beings.

There was no evidence of passion, grit, or growth mindsets. People go to college to get a job. Education is an instrumental act, not a goal in itself. Of course, they are not unusual in this respect. This certainly is nothing new. When HM taught in college, that certainly was the most common response. But students who actually had an intellectual interest in a subject were dearly appreciated. This blog has advocated growth mindsets and lifelong learning as primary goals not only for a fulfilling life, but also as a means of decreasing the likelihood of Alzheimer’s or dementia. Even if they develop the defining neurofibrillary tangles and amyloid plaque, they might well die with these defining symptoms without ever evidencing the behavioral or cognitive symptoms of Alzheimer’s.

The key here is the System 2 processes engaged during learning or critical thinking. Unfortunately, too many people manage to minimize use of System 2 processes even during college. The hope is that at least they engage in activities such as Bridge or Chess, read some books, and stay off Facebook and similar online activities.

© Douglas Griffith and healthymemory.wordpress.com, 2019. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

This is the 1,000th Healthymemory Post

June 3, 2017

As the title attests this blog is dedicated to healthy memories. The blog’s subtitle is Memory health and technology. Here technology refers to transactive memory, which is information that is stored outside our individual biological memories. So transactive memory refers to information stored in the memories of our fellow humans as well as in technology. Technology ranges from paper to computers to the world wide web. Transactive memory provides the means for memory growth which underlies memory health. This blog also addresses the negative aspects of transactive memory which range from erroneous information to outright lies. As several posts have indicated, lies on the internet have become a highly profitable business.

The early days of this blog featured many posts on memory techniques under the category mnemonic techniques. Memory techniques specifically improve memory performance while also affording healthy exercise for the brain. If you are unfamiliar with these techniques you might want to peruse and try out some techniques. Practically all known techniques have been posted, so that is why you need to view older posts. For a while meditation and mindfulness was discussed under the memory techniques category, but they have mostly been moved to Human Memory: Theory and Data. Although these techniques are important and beneficial to memory, they are not commonly regarded as mnemonic techniques.

One of the most important posts in this blog is “The Myth of Alzheimer’s.” “The Myth of Alzheimer’s” by Peter J. Whitehouse, M.D., Ph.D. and Daniel George, M.Sc. is an important book. The myth is that Alzheimer’s is a single disease, and that a drug will be developed that serves as a silver bullet and eradicate Alzheimer’s. Whitehouse is no crackpot. He knows whereof he speaks. Note that he has a Ph.D and an M.D. Although he is now working as a clinician, he spent many years at the forefront of research on drugs to mitigate or eradicate Alzheimer’s disease (AD). He was a prominent researcher who was well funded and promoted by drug companies. When he became convinced that a cure for Alzheimer’s was not forthcoming, he turned his efforts to treatment.

What constitutes a diagnosis of Alzheimer’s is the presence of amyloid plaques and neurofibrillary tangles. However, there are people who are living with these defining features, but who do not have the behavioral or cognitive symptoms of Alzheimer’s. People have died with these Alzheimer features who never knew that they had the disease.

Research indicates that a healthy lifestyle, social activity, and cognitive activity greatly decrease the prospect of suffering any cognitive or behavioral symptoms of Alzheimer’s. The explanation offered for those with the physical characteristics but no cognitive or behavioral symptoms of Alzheimer’s is that they have built up a cognitive reserve.
The healthy memory blog strongly recommends a growth mindset, meditation and mindfulness as being extremely important in thwarting dementia. Central to a growth mindset is to continue learning till the end of one’s life. Beyond thwarting dementia, these activities provide the basis for a fulfilling life.

The vast majority of posts do not deal directly with Alzheimer’s and dementia. This is an exciting era for cognitive neuroscience and this blog endeavors to keep the reader up to date on much of this research. Of course, using technology to foster a growth mindset remains an important topic, and the problem of lies and misinformation being spread by technology is always a concern to the healthymemory blog.

© Douglas Griffith and healthymemory.wordpress.com, 2017. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

Mindfulness and Alzheimer’s

October 15, 2016

This post is taken in part from “Siddhartha’s Brain”  by James Kingsland.  There is evidence that one of the benefits of mindfulness is to slow age-related cognitive decline and perhaps even protect against Alzheimer’s Disease.  Deposits of beta-amyloid, the protein plaques that are characteristic of the disease are concentrated in the default mode network.  This includes its principal hub, the posterior cingulate cortex, and the medial temporal lobe, where structures such as the hippocampus create and store long-term memories.  When people are not focused but performing an externally directed task, the parts of the brain that become active closely match the areas most vulnerable to the damage associated with Alzheimer’s.  Animal research, using mice genetically engineer to develop amyloid plaques, built up exclusively in areas of high nerve activity.

So, in theory, not just mindfulness but any pastime that hold’s the mind’s eye steady and stops attention from wondering, whether it’s a sport  solving puzzles, math, reading, studying, or the mindfulness awareness of everyday activities cultivated by meditation, will give the brain’s default mode network a break and make it less likely that amyloid plaque will accumulate.

Although this is good news, readers of the healthy memory blog should be aware that people have died with the defining physical symptoms, the neurofibril tangles and amyloid plaque, without knowing that they have had the disease.  That is they never evidenced any of the behavioral or cognitive symptoms of he disease.  The explanation for these people is that through the way they used their brains during their lifetimes they built up a cognitive reserve.  The healthy memory blog promotes activities that should build up a cognitive reserve.

Kingsland notes that there is preliminary evidence that meditation can slow or even reverse age-related brain degeneration, helping to maintain the thickness of the cortex and prevent loss of gray matter (nerve cell bodies) and white mater (merve fibers or “axons”.  The reference for this is
Luders, E.  (2014) “Exploring Age-Related Brain Degeneration in Meditation Practioners,”  Annals of the New York Academy of Sciences 1307:82-88.

© Douglas Griffith and healthymemory.wordpress.com, 2016. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

How Do People Circumvent Amyloid Plaque and Neurofibrillary Tangles

July 28, 2015

As has been mentioned in previous healthy memory blog posts, autopsies have found corpses whose brains have been wreaked with amyloid plaque and neurofibrillary tangles, yet who never exhibited any symptoms or behaviors indicating Alzheimer’s.  Yet it is these very substances that provide for a definitive diagnosis of Alzheimer’s.  So at best they are a necessary, but not a sufficient, condition for Alzheimer’s.  See the healthy memory blog post, “The Myth of Alzheimer’s” to learn whether this is actually a disease and whether a drug solution to this problem is possible.  Unfortunately, the money is in the drugs, so that’s where the effort is concentrated.

The explanation offered is that these people with the substances defining the disease, but without the symptoms of the disease, have build up a cognitive reserve.  In other words their brains have a reserve to draw upon that allow them to circumvent the symptoms of the disease.  This is very likely true and this provides strong evidence that we should start early and continue to build this cognitive reserve throughout our lives.

However, I believe that something else is at work, and I believe that is neuroplasticity.  Neuroplasticity refers the ability for the nervous to rebuild and repair itself.  The existence of neuroplasticity is a fairly new finding.  When I was a graduate student the dogma was that neural damage could not be repaired, and this dogma remained in effect until fairly recently.

To learn more about neuroplasticity enter “neuroplasticity” into the healthy memory blog search box.  I wish more research would be put into the preventive and curative effects of neuoplasticity.  As you’ll see if you read or reread “The Myth of Alzheimer’s,” some knowledgeable people do not believe that a drug cure is possible, but that there are other effective avenues to pursue regarding Alzheimer’s or dementia.

© Douglas Griffith and healthymemory.wordpress.com, 2015. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.