Posts Tagged ‘The Myth of Alzheimer’s’

Alzheimer’s Researchers Shift Focus After Failures

July 7, 2019

The title of this post is identical to the title of a front page article by Christopher Rowland in the 4 July 2019 issue of the Washington Post. These researchers are shifting their focus to new drug treatments that deal with other factors than the defining features for an Alzheimer’s diagnose, which are amyloid plaque and neurofibrillary tangles. The conclusion that this research is fruitless was made by a former researcher in this area. The Myth of Alzheimer’s is a book by Peter J. Whitehouse, M.D. and Ph.D and Daniel George, M.Sc. Whitehouse is the former researcher who came to the conclusion that this research would never yield results. There was a healthy memory post on this book in 2011. HM believes Dr. Whitehouse is working on non drug treatments for Alzheimer’s. The Alzheimer’s association provides little, if any, support in this area. The Alzheimer’s association provides financial support for drug research. HM wonders in the unlikely event that a useful drug was produced, whether the Alzheimer’s Association had some agreement to limit costs or would this company be allowed to prey on the public. Before giving any money to the Alzheimer’s association, potential donors should demand an answer to this question.

There have been many posts on this topic including one titled “The Myth of Alzheimer’s.” Perhaps the most significant finding is one that is rarely, if ever, mentioned. And that is that people die with the defining characteristics for an Alzheimer’s diagnosis, the amyloid plaque and neurofibrillary tangles, but who never knew that they had the disease because they never had any behavioral or cognitive symptoms of the disease. The explanation offered is that these people had developed a cognitive reserve as a result of being cognitively active during their lifetimes.

The reappearing theme in this blog is that people should live cognitively fulfilling lives with growth mindsets in which they are continuing to learn. This involves System 2 processing, more commonly referred to as thinking. Our normal processing mode is System 1, which is quite fast and efficient. Here we are in cruise control where the conscious content just keeps flowing. As one proceeds through life this becomes easier and easier. Much has been learned, there is little interest in learning anything new, so the mind effectively is on cruise control. Cognitive neuroscience has termed this the default mode network, which is quite similar, if not identical, to Kahneman’s System 2 processing which is from cognitive psychology.

HM knows people who have been cognitively active throughout their lives, yet still succumbed to Alzheimer’s or dementia. But there are other causes. One of HM’s friends trained himself to get by on 4 hours of sleep per night. Research shows us that 7 to 8 hours of sleep are required. Other ambitious people burn the candle and both ends, which also leads to sleep deprivation.

HM wishes the researchers well in their research. But everyone should know that by engaging in a cognitively challenging life with growth mindsets they should greatly decrease, if not eliminate, the prospect of dementia or Alzheimer’s. Of course, a healthy lifestyle is also assumed.

Please use the search block of the blog (healthymemory.wordpress.com) to learn more about any of the terms in this post.

© Douglas Griffith and healthymemory.wordpress.com, 2019. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

An Infuriating Article About Alzheimer’s

February 11, 2017

And that article is “After many disappointments, the search for Alzheimer’s drugs is more urgent than ever by Melissa Bailey in the Health Section of the 7 February 2017 issue of the Washington Post.  Regular readers of the healthy memory blog should understand why HM is infuriated.  See the healthy memory post, “The Myth of Alzheimer’s.”  The senior author of this book is Peter J. Whitehouse, M.D., Ph.D..  Dr. Whitehouse conducted research for many years into drugs for Alzheimer’s.  He came to the conclusion that effective drugs would never be found, and that research should be concentrated on activities that would prevent, mitigate, or help people suffering with Alzheimer’s.  He remains quite confident that a drug research is a dead end.  Yet it continues.

The reason for this is  money.  Money is in the drugs.  It is especially infuriating that the government is funding this research.  Congress funds this research because it has the appearance of dealing with a serious problem. However, in the highly unlikely case that drugs are found, the drug companies would charge exorbitant fees for them.  Remember that the United States is the only advanced country that does not control drug costs, so perhaps the adjective “advanced” is incorrect.

This drug research is targeted at the neurofibrillary plaque and neurofibril tangles that are the defining symptoms of Alzheimer’s.  Research on the protein tau, is conducted for its role in creating tangles in the brain.  Anti-amyloid drugs  will not work.  Yet there have been many people who have these defining symptoms, but who never exhibit any of the cognitive or behavioral symptoms of Alzheimer’s.  Many people have died, mentally sharp, not knowing that they had Alzheimer’s disease.  By far this is the most significant fact about Alzheimer’s that is rarely, if ever, mentioned.  Apparently, Melissa Bailey, the author of this article, is oblivious of this fact.

The explanation offered for these individuals who have the physical markers, but none of the behavioral symptoms, is that they have built up a cognitive reserve.  Cognitive activity along with a healthy lifestyle greatly decrease the probability of cognitive symptoms.  Just having a purpose in life reduces the risk of cognitive decline by half (see the Healthymemory blog post, “Ikigai Cuts the Risk of Alzheimer’s in Half”).

Consequently the healthy memory blog strongly recommends growth mindsets throughout one’s life.  Becoming a cognitive couch potato greatly increases the risk of Alzheimer’s (enter “Stupidity Pandemic” into the healthy memory blog) to learn more about these risks.

Although there is a widespread use of technology, this technology is used in a superficial manner (see the healthy memory blog post “Notes on Reclaiming Conversation: The Power of Talk in a Digital Age”).  One of the best examples of this is the woman was asked what she thought of “Obamacare”?  She was against it, but when asked what she thought of “The Affordable Care Act,” she thought that was a good idea.

Given the stupidity pandemic and little critical thinking, the incidence of Alzheimer’s will likely increase.  And drugs will not come to the rescue.  People need to start thinking, thinking with purpose, and thinking more deeply.

© Douglas Griffith and healthymemory.wordpress.com, 2017. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.

Superagers with Amazing Memories Have Alzheimer’s Brain Plaques

November 30, 2016

The title of this post is identical to an UpFront News article in the 19 November 2016 issue of the New Scientist.  HM is hoping that healthymemory blog readers are asking, “Is this news?  I thought this was well known!”   Although this is not news, it remains a little known fact in the general public about  Alzheimer’s, when it is the most substantive fact existing about Alzheimers.

The article briefly summarizes work done by Aras Rezvanian and his colleagues at Northwestern University on brain samples donated by superagers to try to understand their exceptional memories.  Of the eight donated samples, two contained so many plaques and tangles that they looked like severe cases of Alzheimer’s.

But to repeat, this finding is not new.  Many such people have died.  Moreover these two individuals were not known to have Alzheimer’s.  After all, they were superagers.  And they died not knowing that they had the definitive symptoms for a diagnosis.

It would be good go  back and read the healthymemory blog “The Myth of Alzheimer’s.”   The senior author of this book is Peter J. Whitehouse, M.D., Ph.D, who was once a researcher earning a lucrative income looking for drugs to mitigate or eradicate Alzheimer’s. He came to the conclusion that such work is fruitless and is now working as a clinician treating and mitigating dementia cases.  Here is his advice, “”It is unlikely that there will ever be a panacea for brain aging and baby boomers should not rely on extraordinary advancements being made in their lifetimes in spite of the promises of the Alzheimer’s Disease (AD) empire that make their way into our headlines. Our attention must begin shifting from mythical cure to hard-earned prevention, from expecting a symptomatic treatment for AD to choosing behaviors that may delay the effects “of cognitve decline over the course of our lives.” Many, if not most, of the behaviors he discusses have been mentioned and advocated in the Healthymemory Blog.

The explanation for people living with the physical symptoms of Alzheimer’s but absent any of the behavioral and clinical symptoms of Alzheimer’s is that they have build up a cognitive reserve.  Cognitive activity, learning new things, is what builds up this cognitive reserve.  There are healthy memory blog posts on theoretical mechanisms for building cognitive reserves, but these posts are hypothetical conjectures.

That cognitive decline can be avoided by staying active has been known at least since the time of the Romans.   The Roman statesman Cicero held a view much more in line with modern-day medical wisdom that loss of mental function was not inevitable in the elderly and “affected only those old men who were weak-willed.”  HM would substitute  “not cognitively active” in the place of “weak-willed.”

When HM taught at a university he was amazed how so many students were able to get their degrees while spending a minimum of cognitive effort.  Other HM blog posts have argued that choices of News shows and political candidates might well be indications of the desire to spend the minimum in the way of cognitive effort.
In closing this post it should be noted that Alzheimer’s is not an inevitable consequence of aging, no matter how great an age is attained.  There are numerous documented supercentenarians (people living to 110+) that experienced no serious cognitive impairment.

© Douglas Griffith and healthymemory.wordpress.com, 2016. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Douglas Griffith and healthymemory.wordpress.com with appropriate and specific direction to the original content.